教师名录
汪海燕，专职副研究员/硕士生导师
主要研究方向：
1.生物芯片制备：微米和纳米级生物传感界面的新型生物芯片设计、开发、制备和测试。
2.微纳界面传感：微纳流体结构设计和动力学模型构建。
3.精准体外诊疗芯片开发，面向临床需求开发快速诊断核心技术。
4.新型单分子蛋白质测序技术。
科研方面：
近年来发表论文近40篇，包括主要包括Advanced Science、Chemical Communications、Analtical Chemistry和ACS Sensor.等，授权专利2项。 担任Result in Chemistry特刊编辑和Chemical Science、ACS Nano、ACS Sensor、Analytical Chemistry等期刊特约审稿人
2019.12-至今 73882必赢欢迎光临网址 73882必赢欢迎光临网址 专职副研究员
2015.02- 2019.10 美国国家标准与技术研究所 Guest Researhcer
Chemical Science
ACS Sensors
ACS Omega
Analytical Chemistry
J Med Chem
Guest Editor of Results in Chemistry
中国分析测试协会纳米分析专业委员会青年委员
中国化学会会员
2013.10 华东理工大学“研究生国家奖学金”
2013.04 华东理工大学“2013年度优秀博士毕业生”
2012.10 华东理工大学“优秀学生干部”
2012.10 华东理工大学“优秀社会工作奖一等奖”
2011.12 华东理工大学“高水平论文奖”
2010.10 华东理工大学计划外奖学金：天鼎东岳一等奖
1. Sun, Y.; Wang, J.; Zhu, Y. Y.; Han, T. T.; Liu, Y.; Wang, H. Y.* Nanoprobes based on optical imaging techniques for detecting biomarkers in liver injury diseases. Coordin. Chem Rev 2025, 524. 216303.
2. Zhao, C.; Sun, W. L.; Huang, X. Y.; Liu, Y.; Wang, H. Y*. Alkaline Phosphatase Activated Near-Infrared Frequency Upconversion Photosensitizers for Tumor Photodynamic Therapy. J Med Chem2024, 67 (15), 13383-13391.
3. Zhao, C.; Sun, W.; Zhu, Y.; Huang, X.; Sun, Y.; Wang, H.-Y.*; Pan, Y.; Liu, Y. An Activatable Heavy-Atom-Free Upconversion Photosensitizer for Targeted Imaging and Treatment of Tumors. J Med Chem 2024, 67 (24), 22322-22331.
4. Chai, Y., Sun Y., Sheng Z., Zhu Y., Du T., Zhu B., Yu H., Dong B., Liu Y., Wang H-Y.*Reversible pH-switchable NIR-II nano-photosensitizer for precise imaging and photodynamic therapy of tumors. Acta Biomaterialia 2024, 188, 315-328.
5. Chai Yun, Shangguan Lina, Yu Hui, Sun Ye, Huang Xiaoyan, Zhu Yanyan, Wang H.-Y.*, Liu Y.* Near Infrared Light-Activatable Platelet-Mimicking NIR-II NO Nano-Prodrug for Precise Atherosclerosis Theranostics. Adv. Sci., 2024, 2304994.
6. He, P.; Wang, H.(共一); Zhu, A.; Zhang, Z.; Sha, J.; Ni, Z.; Chen, Y. Detection of Intrinsically Disordered Peptides by Biological Nanopore. Chem Asian J. 2024, 19 (18), e202400389.
7. Xu, W.; Zou, L.; Wang, H.; Xu, C.; Fan, Q.; Sha, J. Utilizing solid-state nanopore sensing for high-efficiency and precise targeted localization in antiviral drug development. Analyst 2024, 149 (21), 5313-5319.
8. Liu, W.; Ma, C. F.; Wang, H. Y.; Sha, J. J. Conformation Influence of DNA on the Detection Signal through Solid-State Nanopores. Langmuir2024, 40 (18), 9622-9629.
9. Zheng, F.; Li, H. L.; Yang, J.; Wang, H. Y.; Qin, G. L.; Chen, D. P.; Sha, J. J. Improving macromolecule crowding configurations in nanopores for protein sensing. Chem Commun2024.60, 14097-14100.
10. Zheng, F.; Li, H. L.; Yang, J.; Wang, H. Y.; Qin, G. L.; Chen, D. P.; Sha, J. J. A switchable and facile ionic diode modulated by polyethylene glycol. Chem Commun2024. 60, 14471-14474.
11. Han, T. T.; Sun, Y.; Zhao, C.; Wang, H. Y.*; Yu, H.; Liu, Y.Mitochondrial-Targeted Ratiometric Near-Infrared Fluorescence Probe for Monitoring Nitric Oxide in Rheumatoid Arthritis. J Med Chem2024, 67 (5), 4026-4035.
12. Huang, X. Y.; Sun, W. L.; Zhu, Y. Y.; Zhao, C.; Tan, B. J.; Wang, H. Y.*; Liu, Y. A pH/light dual-responsive nanoprodrug to release nitric oxide and ROS for Cascade photodynamic therapy.Sensor Actuat B-Chem.2024, 408.
13. Yu H., Tiemuer A., Yao X., Zuo M., Wang H.-Y.*, Liu Y.*, Chen X*,Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy,Acta Pharmaceutica Sinica B,2024, 14 (1), 378-391.
14. Hui Yu, Yun Chai, Aliya Tiemuer, Yuxuan Han, H.-Y. Wang*, Yi Liu*, Frequency upconversion luminescence: New frontiers in bioapplications, Coord. Chem. Rev., 2023, 496, 215379.
15. Wang J., Sheng Z, Guo J., Wang H.-Y.*, Sun X., Liu Y., Near-Infrared Fluorescence Probes for Monitoring and Diagnosing Nephron-Urological Diseases, Coord. Chem. Rev.2023, 486, 215137.
16. Sun W., Zhao C., Huang X., Tan B., Shangguan L., Liu Y., Wang H.-Y.*, A novel near-infrared chemodosimeter to monitor the change of carboxylesterase in treatment of diabetes, Sens. Actuators B: Chem.,2023, 381, 133416.
17. Zhang Y., Wang J., Sun W., Yu H., An S., Wang H.-Y.*, Liu Y.*, Mitochondria targeted upconversion molecular platform for photodynamic therapy of cancer cells, Dyes and Pigments, 2023, 208,110753.
18. Zhao C., Zhou F., Lu K. Yang S., Tan B., Sun W., Shangguan L., Wang H.-Y.*, Liu Y.*, Near-infrared fluorescent probe for in vivo monitoring acetylcholinesterase activity. Sens. Actuators B: Chem. 2022, 360, 131647.
19. Liu W., Yao X., Zhu W., Wang J., Zhou F., Qian X., Tiemuer A., Yang S., Wang H.-Y.*, Liu Y.*, Azo-Based Hypoxia-Responsive Self-Assembly Near-Infrared Fluorescent Nanoprobe for In Vivo Real-Time Bioimaging of Tumors. ACS Appl. Bio Mater.2021, 4, 3, 2752–2758.
20. Yu H.,Sun W., Tiemuer A., Zhang Y., Wang H.-Y. *, Liu Y.*, Mitochondria targeted near-infrared chemodosimeter for upconversion luminescence bioimaging of hypoxia.Chem. Commun., 2021,57, 5207-5210.
21. Qian X., Zhu W., Yu H., Xu Y., Liu W., Wang H.-Y. *, Liu Y.*,Mitochondria-targeted near-infrared fluorescent probe for monitoring of a Copper(I) in living cells and In vivo,Dyes and Pigments, 2021, 194,109561.
22. Zhu W., Qian X., Wang J., Yu H., Liu W., Wang H.-Y.*, Liu Y.*, Near-infrared frequency upconversion probes for monitoring glutathione S-transferase to evaluate acute liver injury. Sens. Actuators B: Chem.2021, 347, 130640.
23. Zhu W., Yu H., Qian X., Lu K., Zhao C., Zhang Y., Wang H.-Y.*, Liu Y.*, Near-infrared frequency upconversion probe for revealing the relationship between glutathione S-transferase and drug-resistance.Anal. Chim. Acta. 2021, 1181, 338920
24. Wang H.-Y., Kasianowicz J. J., Robertson, J.W.F., Poster L. D., and Ettedgui, J., A Comparison of Ion Channel Current Blockades Caused by Individual Poly (ethylene glycol) Molecules and Polyoxometalate Nanoclusters. The Euro. Phys. J. E.2019,42 (6),83.
25. Wang H.-Y., Zhang H., Chen S., Liu Y.*, Fluorescein-Inspired Near-Infrared Chemodosimeter for Luminescence Bioimaging. Current med. Chem.2019, 26 (21), 4029-4041
26. Wang H.-Y., Ettedgui, J., Forstater, J.H., Robertson, J.W.F., Reiner J. E., Zhang H., Chen S., Kasianowicz, J.J. Determining the physical properties of molecules with nanometer-scale pores. ACS Sens.2018, 3, 251-263.
27. Liu Y., Yao X.-F. & Wang H.-Y.*, Protein Detection Though Single Molecule Nanopore. Chin. J. Anal. Chem.2018, 46, 6, e1838-e1846.
28. Wang, H.-Y., Song, Z.-Y., Zhang, H.-S., & Chen, S.-P. Single-molecule analysis of lead (II)-binding aptamer conformational changes in an α-hemolysin nanopore, and sensitive detection of lead (II). Microchim. Acta2016, 183,1003-1010.
29. Wang, H.-Y., Gu, Z., Wang, J., & Long, Y.-T. Analysis of a single α-synuclein fibrillation by the interaction with a protein nanopore. Analy. Chem.2013, 85, 8254-8261.
30. Wang, H.-Y., Li, Y., Qin, L.-X., Heyman, A., Shoseyov, O., Willner, I., Long, Y.-T., & Tian, H. Single-molecule DNA detection using a novel SP1 protein nanopore. Chem. Commun.2013, 49, 1741-1743.
31. Wang, H.-Y., Ying, Y.-L., Li, Y., Kraatz, H.B., & Long, Y.-T. Nanopore analysis of β-amyloid peptide aggregation transition induced by small molecules. Anal. Chem.2011, 83, 1746-1752.
32. Wang, H.-Y., Ying, Y.-L., Li, Y., & Long, Y.-T. Peering into Biological Nanopore: A Practical Technology to Single‐Molecule Analysis. Chem. An Asian J.2011, 5, 952-1961.
33. Liu Y., Wang S., Ma Y., J Lin, Wang H.-Y., Gu Y., Chen X., Huang P. Ratiometric photoacoustic molecular imaging for methylmercury detection in living subjects. Advanced Mater. 2017, 29, 1606129.
34. Kasianowicz, J.J., Balijepalli, A.K., Ettedgui, J., Forstater, J.H., Wang, H.-Y., Zhang, H., & Robertson, J.W.F. Analytical applications for pore-forming proteins. Biochim. Biophy. Acta – Biomembran.2016, 1858, 593-606.
35. Ying, Y.-L., Wang, H.-Y. Sutherland, T.C. & Long, Y.-T. Monitoring of an ATP‐Binding Aptamer and its Conformational Changes Using an a-Hemolysin Nanopore. Small2011, 1, 87-94.
36. Liu, Y., Ying, Y.-L., Wang, H.-Y., Cao, C., Li, D.-W., Zhang, W.-Q., & Long, Y.-T. Real-time monitoring of the oxidative response of a membrane–channel biomimetic system to free radicals. Chem. Commun.2013, 49, 6584-6586.
37. Liu, T., Bao, C., Wang, H.-Y., Lin, Y., Jia, H., & Zhu, L. Light-controlled ion channels formed by amphiphilic small molecules regulate ion conduction viacis–trans photoisomerization. Chem. Commun.2013, 49, 10311-10313.
38. 喻皓，汪海燕，龙亿涛等基于LabVIEW的纳米通道单分子检测系统，授权专利号：ZL 2010 2 0169643.6
39 汪海燕，郭小喆，陈云飞，复合柔性微流道固态纳米孔检测液池装置，发明专利申请号：202510607742.9
2020.01-2020.12, 项目主持人，中央高校基本业务费基础科研扶持项目-理工类：基于纳米孔的生物仿生界面机械性能研究（2242020K40221）
2014.09-2016.12, 项目主持人, 中国博士后科学基金第56批一等资助项目：纳米通道用于核酸适配体单分子识别行为研究（2014M560670）
2021.01-2024.12 项目参与人，国家自然科学基金面上项目：固态纳米孔核酸检测的关键技术和机理 (52075099)
2024.11- 2027.10 国家重点研究发计划子课题负责人：高时空分辨的阵列纳米孔道芯片及信号提取（2023YFF1205802），30万，在研
2024.01- 2026.12 项目参与人，国际(地区)合作与交流项目：基于纳米流体离子晶体管的集成离子电路（52361145851）200万元，在研
喻皓，汪海燕，龙亿涛等基于LabVIEW的纳米通道单分子检测系统，授权专利号：ZL 2010 2 0169643.6
汪海燕，郭小喆，陈云飞，复合柔性微流道固态纳米孔检测液池装置，发明专利申请号：202510607742.9
